IndraLab

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USP14 deubiquitinates CGAS. 3 / 3
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"Here, we discovered that TRIM14 recruited USP14 to inhibit ubiquitination of cGAS."
27666593
reach
"USP14 inactive mutants (C114A) ( Lee et al., 2010 ) neither inhibited K48-linked ubiquitination of cGAS nor stabilized cGAS, indicating that USP14 affected cGAS stability in a protease-dependent manne[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27666593
reach
"TRIM14 has been reported to interact with cGAS via its PRYSPRY domain and upon DNA virus infection recruit the proteasome associated deubiquitinase (DUB) USP14 to deubiquitinate cGAS, preventing recruitment of p62 and autophagy dependent degradation of cGAS."
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