IndraLab

Statements

TP53 binds OTUD4. 4 / 4
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"Endogenous OTUD4–p53 interaction was confirmed in wild-type p53 HCT116 cells using Co-IP assays (Fig.  xref B)."
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"Taken together, our data demonstrate that OTUD4 attenuates the aggressiveness of colorectal cancer cells in a p53-dependent manner—reinforcing the critical role of the OTUD4–p53 axis in CRC suppression."
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"Mechanistically, OTUD4 binds p53, attenuates its ubiquitination, enhances p53 stability, and activates p53-mediated transcription, thereby inducing cell-cycle arrest and apoptosis."
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"Critically, p53 knockdown abrogates OTUD4-mediated suppression of malignant phenotypes, establishing the OTUD4-p53 axis as a critical regulatory node in CRC."
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