IndraLab

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UCHL3 binds SLC11A1. 2 / 2
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"At the same time, the lncRNA GIAT4RA counteracts the deubiquitinating effects of LSH by interfering with interaction between LSH and UCH-L3, reducing levels of LSH protein, and playing the role in inhibiting the invasion and migration of LUAD cells83."
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"However, HOTAIR was also reported to reduce the ubiquitination degradation of AR by preventing its combination with MDM2, and GIAT4RA was recently reported to interfere the interaction between Uchl3 and LSH to repress ubiquitin-proteasome pathway [30], which indicate multiple roles of lncRNA in ubiquitination."
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