IndraLab

Statements

USP37 deubiquitinates BLM. 7 / 7
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"Correction to 'USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM'."
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"USP37 deubiquitinates BLM in vivo and in vitro."
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"Moreover, knockdown of USP37 increases BLM polyubiquitination, accelerates its proteolysis, and impairs its function in DNA damage response."
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"In this study, we demonstrate that USP37 deubiquitinates and stabilizes BLM."
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"In addition, WT USP37, but not the CA mutant, decreased BLM polyubiquitination in vitro (Figure 3D, and Supplementary Figure S2A, B)."
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"Since USP37 inhibits the ubiquitination of BLM following DNA damage, we further explored whether and how USP37 itself is regulated following DNA damage."
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"Here, we demonstrate that the deubiquitinating enzyme USP37 interacts with BLM and that USP37 deubiquitinates and stabilizes BLM, thereby sustaining the DNA damage response (DDR)."
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