IndraLab

Statements

Ethanol inhibits MAPK8. 4 / 4
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"In rat heart, direct alcohol feeding led to a reduction of apoptotic cardiomyocyte death by reducing apoptotic signaling cascades, JNK-1 and c-Jun, and activating heat shock protein (HSP) 70, heme oxygenase and superoxide dismutase."
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"Furthermore, alcohol dehydrogenase is involved in the relationship between ethanol-induced inactivation of p-JNK1/2 and the changes of the IGF-I system and cell viability."
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"In contrast, co-administration of folecitin (30 mg/kg body weight) reduced ethanol-induced oxidative stress, inhibited p-JNK, and deactivated the NLRP3-inflammasome complex."
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"To clarify the individual role of JNK1 or JNK2 on acute alcohol induced steatosis, either JNK1 knockout or JNK2 knockout mice were treated with acute alcohol."
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