IndraLab

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USP18 deubiquitinates ZEB1. 5 / 5
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"Another agent promoting EMT is ZEB1 deubiquitinated by ubiquitin-specific peptidase 18 (USP18) in esophageal squamous cell carcinoma, while overall SUMOylation is associated with cancer progression [81]."
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"In a similar vein, USP18 was determined to bolster tumour proliferation, migration, and invasion by deubiquitinating ZEB1 and Snail1 and solidifying their expression [18, 19]."
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"In the current study, our results demonstrated that USP18 directly interacted with ZEB1 and suppressed the poly-ubiquitination of ZEB1, thereby stabilising ZEB1 expression in human ESCC cells."
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"USP18 interacted with ZEB1 and reduced the poly-ubiquitination of ZEB1, thereby stabilising ZEB1 and leading to the induction of the EMT process ( Fig. 5 G)."
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"USP18 also deubiquitinates ZEB1 and enhances EMT and metastasis in oesophageal squamous cell carcinomas."
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