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KCNH2 activates KCN. 13 / 13
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"11 In contrast, the risk of LTE among men is attenuated after the onset of adolescence.7, 8, 9 The mechanisms underlying the influence of sex hormones on cardiac repolarization are complex and are not completely understood.Sex hormones have varying effects on I (Kv7.1) and I (Kv11.1) currents.14 Testosterone increases the potassium channel currents, resulting in a shorter QTc in both animal and human studies."
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"KCNH2 encodes a voltage-activated potassium channel that has been mainly indicated as playing a role in long QT syndrome [32, 33]."
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"Expert opinionFor reprint orders, please contact : ben.fisher@informa.comReviewCardiovascular & RenalThe hERG potassium channel as a therapeutic targetHarry J WitchelUniversity of Bristol, School of Medical Sciences, Department of Physiology, Bristol, BS8 1TD, UKThe hERG (human ether-a-go-go-related gene) potassium channel has elicited intense scientific interest due to its counter-intuitive kinetics and its association with arrhythmia and sudden death."
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"The effects of Aspidasept on hERG-mediated potassium channel currents were investigated by theoretical molecular docking, and experimentally by manual and by planar patch-clamp electrophysiology."
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"No effects of Aspidasept on hERG-mediated potassium channel currents were observed."
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"For example, congenital long QT syndrome is caused by mutations in the human ether-a-go-go-related gene (HERG) encoding a potassium channel."
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"These studies all suggest that potassium channel functional deficits caused by KCNH2 polymorphisms are related to not only LQT2 but also to epileptic attacks."
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"In vitro, ZZUNEUi027-A cell line could be differentiated into cardiomyocytes and could be a cell disease model to study LQT2 pathogenic mechanisms.The KCNH2 gene encodes a voltage-activated potassium [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This results in a large hERG-mediated tail current that is observed in the second partial depolarization phase to −50 mV.Aspidasept (Pep19-2.5) was applied at nominal concentrations of 1 µg/mL, 10 µg/mL, and 100 µg/mL, and remaining hERG mediated potassium channel currents normalized to initial currents were calculated."
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"SCN5A encodes an alpha subunit of voltage-gated Na + channel while KCNH2 transcripts encode a voltage-activated potassium channel (hERG)."
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"It has been long demonstrated that hERG-mediated potassium channels effectively control the duration of the action potential and QT interval, which is detected in electrocardiograms [30,31]."
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"HERG codes for a voltage activated potassium channel that is especially important during the repolarization phase of the action potential."
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"mRNA levels of the KCNH2 unit of the rapidly (I Kr) activating delayed rectifier potassium channel and KCNQ1/2 [(two members of the potassium voltage gated channel subfamily Q of the slowly (I Ks) act[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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