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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTUB1 inhibits DNA damage checkpoint. 3 / 3

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"Although OTUB1 functions downstream of ATM in response to DNA damage, because pharmaceutical inhibition of the ATM is partial, removal of the DDR negative regulator OTUB1 would increase the DNA damage response."

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"Recent study indicated that OTUB1 is an inhibitor of the DNA damage response that suppresses poly- but not mono-ubiquitination [XREF_BIBR]."

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"We recently reported that OTUB1, a deubiquitylase, inhibits the DNA damage response independently of its isopeptidase activity."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

OTUB1 inhibits DNA damage checkpoint. 3 / 3

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