IndraLab

Statements

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"Although OTUB1 functions downstream of ATM in response to DNA damage, because pharmaceutical inhibition of the ATM is partial, removal of the DDR negative regulator OTUB1 would increase the DNA damage response."
29167269
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"Recent study indicated that OTUB1 is an inhibitor of the DNA damage response that suppresses poly- but not mono-ubiquitination [XREF_BIBR]."
21461879
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"We recently reported that OTUB1, a deubiquitylase, inhibits the DNA damage response independently of its isopeptidase activity."
22325355