IndraLab

Statements

FYN phosphorylates SCN9A on tyrosine. 5 / 5
| 4 1
rlimsp
"Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner."
29790812
reach
"Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner."
29790812
reach
"Fyn caused a robust increase in Nav1.7 tyrosine phosphorylation (Figure 3(a)), suggesting that Nav1.7 is a substrate for Fyn kinase."
29790812
reach
"Our results demonstrate Fyn -mediated upregulation of Nav1.7 protein expression and tyrosine phosphorylation and identify two tyrosine residues within the DIII-DIV linker (L3) as Fyn phosphorylation sites."
29790812
reach
"The beads were washed with Triton X-100-free RIPA buffer, and proteins coimmunoprecipitated with Nav1.7 were eluted with NuPAGE LDS sample buffer plus DTT and examined by Western blot.To examine Fyn-mediated tyrosine phosphorylation of Nav1.7 channels, HEK-Nav1.7st cells were transfected with Fyn -mCherry or Fyn -mCherry."
29790812