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NKX2-5 activates HCN4. 2 / 2
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"For example, TBX3 represses the ANP gene in the SAN, while in the adjacent atrial myocardium, NKX2.5 activates ANP and represses HCN4 and TBX3, as evidenced by ectopic expression of TBX3 and HCN4 in the embryonic myocardium of Nkx2.5 null mice ( xref )."
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"Although the loss of either Nkx2-5 or Pitx2 results in the ectopic pacemaker phenotype, inactivation of Pitx2 leads to an acquirement of the complete pacemaker program in the left SV-atrial junction, whereas haploinsufficiency of Nkx2-5 causes only an upregulation of Hcn4 in the Pitx2 + left sided structure, suggesting that these two genes repress pacemaker program through independently functional mechanisms [XREF_BIBR, XREF_BIBR]."
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