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OTUD7B increases the amount of PIK3C2A. 3 / 3
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"All these results suggested that Cezanne might promote PIK3C2A transcription, but not protein stability.As we did not find any report that Cezanne could serve as a transcriptional factor (TF) or co-activator, we tried to identify the mediator between Cezanne and PIK3C2A."
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"All these indicated that Cezanne could induce PIK3C2A expression by stabilizing PLOR2A."
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"All these results suggested that Cezanne could act as a deubiquitination enzyme to deubiquitinate K48-linked ubiquitination and stabilize POLR2A, then promote the transcription of PIK3C2A in a POLR2A-dependent way.In our study, Cezanne colocalized with PIK3C3 and stabilized PIK3C3 by slowing down its ubiquitin-proteasome pathway degradation (Fig. 3), and we also found Cezanne promoted PIK3C2A transcription (Fig. 5)."
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