IndraLab

Statements

REST decreases the amount of USP37. 3 / 3
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"REST also represses the transcription of the anti-proliferative deubiquitylase USP37, and drugs that reactivate USP37 expression may have therapeutic applications [XREF_BIBR]."
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"Previously, we observed that the expression of USP37 is transcriptionally repressed by the RE1 Silencing Transcription Factor (REST), which requires chromatin remodeling factors for its activity."
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"Conversely, REST knockdown upregulated USP37 gene expression and promoted an increase in p27 protein levels."
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