IndraLab

Statements

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"USP7 downregulation promotes lung cancer cell apoptosis."
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"9 We also found previously that the overexpression of HAUSP leads to cancer cell apoptosis."
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"Consequently, USP7 has emerged as an attractive oncology target because its inhibition stabilizes p53, thereby promoting p53 dependent apoptosis in cancer cells."
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"By investigating several linker and E3 ligand types, including novel cereblon recruiters, we discovered a highly selective USP7 degrader tool compound that induced apoptosis of USP7-dependent cancer cells."
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"USP7 promotes colorectal cancer cell apoptosis by directly stabilizing p53 ."
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"P5091 is a novel USP7 specific small molecule inhibitor that induces apoptosis in multiple myeloma cells resistant to conventional and bortezomib therapies through stabilization of p53."
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"This is underscored by recent findings showing that HAUSP can be used to therapeutically target p53 independent apoptosis responses in certain tumors."
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"Besides, study has shown that the expression of USP7 was upregulated in H9C2 cardiomyocytes cultured under hypoxia and in the heart of MI rats, and overexpression of USP7-induced inflammation and apoptosis of cardiomyocytes, leading to aggravation of MI injury."
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"Silencing of USP7 by siRNAs or its inhibitors recued cell proliferation and accelerated apoptosis in chondrocyte."
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"Then it was confirmed that USP7 knockdown suppressed proliferation (Fig. 4A) and induced apoptosis (Fig. 4B) in SiHa and HeLa cells."
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"These data suggested ART might act on USP7/BCR-ABL therefore inducing CML cell apoptosis."
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"45 The aberrant activities of USP7 and HDM2 suppress the normal function of P53 and thereby disrupt the natural processes of apoptosis and cell-cycle progression in cells, which may contribute to cancer initiation."
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"As the s, P5091 is also an elective dual-inhibitor of USP7 and USP47 that can suppress CRC cell growth and induces their apoptosis in vitro (An et al., 2017)."
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"Our previous study found that USP7 overexpression aggravated hypoxia-induced apoptosis of cultured cardiomyocytes and LVR and left ventricular dysfunction after MI in rats [9]."
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"We discovered that USP7 silencing promoted cell viability and inhibited cell apoptosis in the cells, but these effects were relieved after TRAF1 overexpression (Fig. 4C-F)."
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"In addition, inhibition of USP7, in combination with inhibition of PIM kinase and PI3K, which activate mTOR, synergistically reduce cell proliferation and promote apoptosis in AML cells."
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"In the present study, we also found that both USP7 knockout in HeLa cells and treatment with USP7 inhibitors in SH-SY5Y cells increased ER stress-induced cytotoxicity and apoptosis."
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"Collectively, these data indicated that deficiency of FOXO6 transcriptionally deregulated expression of USP7 and induced USP7 mediated apoptosis."
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"Inhibition of USP7 reduces the apoptosis of cardiomyocytes."
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"The knockdown of USP7 or its inhibitor decreased chondrocyte proliferation and accelerated apoptosis and inflammatory response under inflammation."
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"HAUSP also induced p53-dependent cell growth repression and apoptosis."
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"Furthermore, research suggests that overexpression of USP7 in human tumors inhibited tumor cell cycle arrest and promoted apoptosis, thereby promoting tumor progression."
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"Knock-down of GMPS prevents p53 stabilization in response to genotoxic stress 59, while concomitant overexpression of both USP7 and GMPS leads to p53 stabilization and apoptosis, even in the absence of genotoxic stress 59."
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"Similarly, in the I/R group, TUNEL staining results showed a substantial increase in the number of positive cells, while inhibition of USP7 reduced apoptosis (Fig. 3e–h)."
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"These results suggest that inhibition of USP7 can suppress apoptosis of cardiomyocytes."
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"The overexpression of USP7/HAUSP induces cancer cell apoptosis, and this phenotype depends on p53 existence in the cells [25]."
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"HAUSP strongly stabilizes p53 even in the presence of excess Mdm2, and also induces p53 dependent cell growth repression and apoptosis."
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"Pharmaceutical or genetic inactivation of USP7 inhibited esophageal cancer cells growth in vitro and in vivo and induced apoptosis."
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"In this study, we demonstrated that loss of USP7 function inhibits cell growth by promoting cell cycle arrest and apoptosis in A375 and B16 cells."
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"The results indicated that overexpression of USP7 mediated apoptosis by regulating the p53-MDM2 pathway, which resulted in the upregulation of the Bad phosphorylation."
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"Augmentation of USP7 expression led to a dramatic promotion of hypoxia induced apoptosis of cardiomyocytes, accompanied by an increase in the secretion of the cytokines IL-1beta, TNF-alpha, and IL-6."
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"However, HAUSP downregulation causes resistance to Camptothecin- and irradiation induced apoptosis, which correlates with suppressed mitochondrial translocation of p53."
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"Our results show that inhibition of USP7 by small molecule inhibitors or genetic depletion by small interfering RNA (siRNA) can selectively induce apoptosis in several types of SCs in part via restori[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP7 knockdown suppresses OSCC cell proliferation and induces cell apoptosis."
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"We tentatively reached this conclusion by observing apoptosis induced by the application of the suppression system of USP7."
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"USP7 as a context specific modulator mediates p53 dependent apoptosis via controlling MDM2 stability."
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"These data suggested that USP7 knockdown inhibited HSC3 cell proliferation by regulating cell cycle and cyclin-dependent kinase inhibitors-related proteins, thus promoting HSC3 cells apoptosis by upregulating pro-apoptotic related protein."
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"USP7 was shown to deubiquitinate and stabilize the ERα subunit, promoting cell proliferation and tumor growth in ER-positive BC by inhibiting cell cycle arrest and apoptosis [35]."
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"When a decrease in USP7 levels leads to MDM2 degradation, the available MDM2 levels become insufficient for ubiquitination, which stabilizes p53.The USP7/p53/MDM2 axis remains one of the cornerstones of the USP7 pathway in the nucleus, and fresh studies continue to illustrate how USP7 promotes p53-dependent apoptosis in disease."
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"On one hand, USP7 was discovered to directly deubiquitinate and stabilize p53 to inhibit tumor cell growth and activate apoptosis [62]."
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"It is reported that USP7 inhibitors sensitize various cancer cells to PARP-inhibitor drugs.28,29 In addition, small-molecule compounds that inhibit USP7 deubiquitinating activity induce cancer cell line apoptosis via the p53 pathway.30,31 P5091 is a reported selective USP7 inhibitor and it inhibited Wnt-β-catenin pathway and contributes to the apoptosis of colon cancer cells."
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"Interestingly, the level of phosphorylated Bad was also downregulated by USP7 knockdown, and dephosphorylated Bad can interact with Bcl-2 and Bcl-xL in mitochondria, thereby inactivating these anti-apoptotic proteins and inducing apoptosis [XREF_BIBR]."
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"Overexpression of USP7 has been found to result in increased p53 stabilization and therefore increased cell cycle arrest and apoptosis XREF_BIBR."
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"Still, the USP7-MDM2-p53 axis remains the paradigm of USP7 interactions in the nucleus, and new research continues to show how USP7 promotes p53 dependent apoptosis in disease."
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"USP7 ubiquitination at Lys869 by E3 ligase TRIM27 promotes the TNF-alpha-induced apoptosis through deubiquitination of RIPK1 and the role of phosphorylation at Ser963 remains to be determined."
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"Furthermore, direct depletion of USP7, while not altering p53 levels, promoted apoptosis and inhibited productive replication in PEL cells, indicating the overall importance of USP7 activity in HHV-8 biology."
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"The overexpression of USP7 leads to changes in DNA damage response, apoptosis and cell cycle, thus causing tumor progression."
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"USP7 overexpression significantly alleviated neurological deficits, reduced infarct volume, attenuated histological damage, and decreased neuronal apoptosis in the MCAO/R model."
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"The DUB inhibitor ubiquitin-specific protease (USP7) enhances caspase-dependent apoptosis during ferroptosis while degrading GPX4, which results in ubiquitinated protein accumulation and cell death (163)."
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"USP7 overexpression aggravated LPS-induced HPMEC apoptosis, inflammation, oxidative stress, and M1 macrophage polarization."
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"Overexpression of USP7 led to stabilization of p53 and induced p53 dependent growth repression and apoptosis."
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"Silencing of USP7 inhibits inflammation and cell apoptosis in ALI mouse."
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"In chronic lymphocytic leukemia (CLL), USP7 inhibition arrests cell growth and induces p53 independent apoptosis by restoring PTEN in the nucleus [XREF_BIBR]."
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"Here we show that ubiquitin-specific peptidase 7 (USP7) is a novel target for senolysis because inhibition of USP7 with an inhibitor or genetic depletion of USP7 by RNA interference induces apoptosis selectively in SnCs."
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"USP7 was also implicated to modulate tumor growth and apoptosis in a colon carcinoma xenograft model."
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"Likewise, HAUSP is partially cleaved during TCR mediated thymocyte apoptosis, albeit less efficiently."
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