IndraLab

Statements

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"USP7 knockdown suppresses OSCC cell proliferation and induces cell apoptosis."
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"USP7 ubiquitination at Lys869 by E3 ligase TRIM27 promotes the TNF-alpha-induced apoptosis through deubiquitination of RIPK1 and the role of phosphorylation at Ser963 remains to be determined."
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"Furthermore, direct depletion of USP7, while not altering p53 levels, promoted apoptosis and inhibited productive replication in PEL cells, indicating the overall importance of USP7 activity in HHV-8 biology."
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"9 We also found previously that the overexpression of HAUSP leads to cancer cell apoptosis."
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"In this study, we demonstrated that loss of USP7 function inhibits cell growth by promoting cell cycle arrest and apoptosis in A375 and B16 cells."
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"USP7 as a context specific modulator mediates p53 dependent apoptosis via controlling MDM2 stability."
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"Pharmaceutical or genetic inactivation of USP7 inhibited esophageal cancer cells growth in vitro and in vivo and induced apoptosis."
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"The overexpression of USP7/HAUSP induces cancer cell apoptosis, and this phenotype depends on p53 existence in the cells [25]."
| PMC
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"These data suggested ART might act on USP7/BCR-ABL therefore inducing CML cell apoptosis."
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"However, HAUSP downregulation causes resistance to Camptothecin- and irradiation induced apoptosis, which correlates with suppressed mitochondrial translocation of p53."
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"In chronic lymphocytic leukemia (CLL), USP7 inhibition arrests cell growth and induces p53 independent apoptosis by restoring PTEN in the nucleus [XREF_BIBR]."
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"The results indicated that overexpression of USP7 mediated apoptosis by regulating the p53-MDM2 pathway, which resulted in the upregulation of the Bad phosphorylation."
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"By investigating several linker and E3 ligand types, including novel cereblon recruiters, we discovered a highly selective USP7 degrader tool compound that induced apoptosis of USP7-dependent cancer cells."
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"Interestingly, the level of phosphorylated Bad was also downregulated by USP7 knockdown, and dephosphorylated Bad can interact with Bcl-2 and Bcl-xL in mitochondria, thereby inactivating these anti-apoptotic proteins and inducing apoptosis [XREF_BIBR]."
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"USP7 downregulation promotes lung cancer cell apoptosis."
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"These data suggested that USP7 knockdown inhibited HSC3 cell proliferation by regulating cell cycle and cyclin-dependent kinase inhibitors-related proteins, thus promoting HSC3 cells apoptosis by upregulating pro-apoptotic related protein."
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"Likewise, HAUSP is partially cleaved during TCR mediated thymocyte apoptosis, albeit less efficiently."
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"USP7 was also implicated to modulate tumor growth and apoptosis in a colon carcinoma xenograft model."
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"Collectively, these data indicated that deficiency of FOXO6 transcriptionally deregulated expression of USP7 and induced USP7 mediated apoptosis."
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"Silencing of USP7 inhibits inflammation and cell apoptosis in ALI mouse."
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"Knock-down of GMPS prevents p53 stabilization in response to genotoxic stress 59, while concomitant overexpression of both USP7 and GMPS leads to p53 stabilization and apoptosis, even in the absence of genotoxic stress 59."
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"This is underscored by recent findings showing that HAUSP can be used to therapeutically target p53 independent apoptosis responses in certain tumors."
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"The knockdown of USP7 or its inhibitor decreased chondrocyte proliferation and accelerated apoptosis and inflammatory response under inflammation."
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"Consequently, USP7 has emerged as an attractive oncology target because its inhibition stabilizes p53, thereby promoting p53 dependent apoptosis in cancer cells."
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"USP7 silencing in HL-60 cells (Supplementary Fig. 1A) significantly reduced cell proliferation (Fig. 1a) by increasing apoptotic cell death (Fig. 1b) and the proportion of cells in the G1 phase (Fig. 1c)."
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"Augmentation of USP7 expression led to a dramatic promotion of hypoxia induced apoptosis of cardiomyocytes, accompanied by an increase in the secretion of the cytokines IL-1beta, TNF-alpha, and IL-6."
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"Overexpression of USP7 has been found to result in increased p53 stabilization and therefore increased cell cycle arrest and apoptosis XREF_BIBR."
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"P5091 is a novel USP7 specific small molecule inhibitor that induces apoptosis in multiple myeloma cells resistant to conventional and bortezomib therapies through stabilization of p53."
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"We tentatively reached this conclusion by observing apoptosis induced by the application of the suppression system of USP7."
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"HAUSP strongly stabilizes p53 even in the presence of excess Mdm2, and also induces p53 dependent cell growth repression and apoptosis."
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"Here we show that ubiquitin-specific peptidase 7 (USP7) is a novel target for senolysis because inhibition of USP7 with an inhibitor or genetic depletion of USP7 by RNA interference induces apoptosis selectively in SnCs."
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"Still, the USP7-MDM2-p53 axis remains the paradigm of USP7 interactions in the nucleus, and new research continues to show how USP7 promotes p53 dependent apoptosis in disease."
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