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USP29 activates AURKB. 5 / 5
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"On the other hand, depletion of endogenous USP29 using sgRNAs or shRNAs significantly decreased the AURKB protein abundance, but showed minimal effects on AURKB mRNA level (Fig. 3B and C and Supplementary Fig. 3A), indicating that USP29 regulates AURKB expression at the protein level."
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"Here we found that USP29 rescued CDH1-mediated decrease of AURKB and proteasome inhibitor MG132 treatment also rescued the AURKB downregulation induced by USP29 depletion (Fig. 3D and E)."
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"Consistently, depletion of endogenous USP29 in MGC-803 cells using sgRNAs significantly accelerated degradation of endogenous AURKB (Fig. 3G)."
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"USP29 activation mediated by FUBP1 promotes AURKB stability and oncogenic functions in gastric cancer."
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"USP29 enhances AURKB protein stability."
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