IndraLab

Statements

OTUB1 increases the amount of MDM4. 5 / 5
| 5
reach
"Overexpression of Otub1 markedly stabilized MDMX and induced its levels, whereas knockdown of Otub1 reduced the levels of MDMX."
28035068
reach
"Consistently, knockdown of endogenous Otub1 by two different siRNAs significantly reduced the levels of MDMX in cells."
28035068
reach
"These results suggest that Otub1 increases the cytoplasmic levels of both MDMX and p53."
28035068
reach
"Consequently, overexpression of Otub1 markedly stabilized MDMX and increased its levels, whereas knockdown of Otub1 reduced the levels of MDMX."
28035068
reach
"Doxycycline induced expression of Otub1 in T-Rex-U2OS-Flag-Otub1 cells also drastically induced the levels of MDMX, as well as p53 and its target MDM2 in a time dependent manner."
28035068