IndraLab

Statements

RyR binds CACNA1C. 5 / 5
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sparser
"We did not perform immunoprecipitation to determine the potential nature of the interaction between RyR and L type channels since this experiment would only determine a biochemical but not a physiological interaction."
23826376
sparser
"Loss of Kv2.1 expression was also associated with a decrease in Ca 2+ spark frequency, likely because of decreased spatial association of Cav1.2 and RyRs, decreased RyR cluster size, and decreased LTCC currents."
31663850
sparser
"We hypothesize that this result is a consequence of the decreased spatial association of Cav1.2 and RyRs, decreased RyR cluster size, and decreased open probability of LTCCs in Kv2.1 KO neurons."
31663850
sparser
"Taken together, these findings demonstrate that Kv2.1 channels promote the spatial and functional association of endogenous Cav1.2 and RyRs in neurons, as well as the corresponding exogenous channels in HEK293T cells."
31663850
sparser
"cBIN1 mediates T-tubule functions and cardiac Ca machinery by forming microfolds in the T-tubules [ xref , xref ], aiding in the clustering and forward-trafficking of the L-type calcium channel (LTCC) or Cav1.2 to T-tubules [ xref , xref ], recruiting RyRs to dyads [ xref ], and eventually leading to RyR–Cav1.2 coupling at the dyads [ xref , xref ]."
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