IndraLab

Statements

CACNA1C binds RyR. 4 / 4
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sparser
"Loss of Kv2.1 expression was also associated with a decrease in Ca 2+ spark frequency, likely because of decreased spatial association of Cav1.2 and RyRs, decreased RyR cluster size, and decreased LTCC currents."
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sparser
"We hypothesize that this result is a consequence of the decreased spatial association of Cav1.2 and RyRs, decreased RyR cluster size, and decreased open probability of LTCCs in Kv2.1 KO neurons."
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sparser
"We did not perform immunoprecipitation to determine the potential nature of the interaction between RyR and L type channels since this experiment would only determine a biochemical but not a physiological interaction."
23826376
sparser
"Taken together, these findings demonstrate that Kv2.1 channels promote the spatial and functional association of endogenous Cav1.2 and RyRs in neurons, as well as the corresponding exogenous channels in HEK293T cells."
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