IndraLab

Statements

USP3 binds DDX58. 7 / 7
2 | 5
biogrid
No evidence text available
24366338
reach
"Because it was recently shown that USP3 interacts with RIG-I to deubiquitinate K63 linked poly-ubiquitin chains on RIG-I and inhibit type I IFN pathways [XREF_BIBR], we focused on SRSF1 for further experiments."
25658361
reach
"We found that USP3 and a splicing-factor oncoprotein, serine/arginine rich splicing factor 1 (SRSF1), interact with RIG-I."
25658361
biogrid
No evidence text available
24366338
reach
"Coimmunoprecipitation and western blot analyses revealed that USP3 and SRSF1 specifically interact with RIG-I in vitro (XREF_FIG and XREF_SUPPLEMENTARY)."
25658361
reach
"USP3 binds RIG-I and removes the K63-polyubiquitin chains on the N-terminal CARDs [XREF_BIBR]."
28295214
reach
"Upon virus infection, USP3 interacted with RIG-I, likely acting as a negative feedback regulator."
25753787