IndraLab

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KLF3-AS1 activates USP22. 3 / 3
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"Here, we validated that KLF3-AS1 sponged miR-206 to downregulate its level, thereby upregulating USP22."
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"KLF3-AS1 induced USP22 to promote the deubiquitination of Sirt1 protein."
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"Furthermore, overexpression of KLF3-AS1 upregulated Sirt1 and USP22, but silencing of USP22 reversed these effects (Fig. 4C)."
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