IndraLab

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BAP1 deubiquitinates MYCN. 4 / 4
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"Taken together, these data suggest that the BAP1 is likely an upstream DUB of MYCN to deubiquitinate and stabilize MYCN protein."
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"E3 ubiquitin ligases such as FBXW7 could promote MYCN ubiquitination and degradation, however, BAP1 deubiquitinates MYCN and increases its stability."
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"Inhibiting BAP1 by shRNA-mediated knockdown decreases the expression of MYCN largely through reducing the BAP1-mediated deubiquitination of MYCN."
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"Notably, BAP1 could reduce the polyubiquitination of MYCN (Fig. 1I), which might be the underlying mechanism for the effect of BAP1 on extend half-life of MYCN."
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