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AURKA binds CALM1. 12 / 12
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"In order to achieve this, the region between nucleotides 7242 and 8082 of the CAM-70 H cDNA was replaced with the corresponding region of the AIK-C H gene using the restriction enzymes PacI and NdeI, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly, the region between nucleotides 8082 and 9175 of the CAM H cDNA was replaced with the corresponding region of the AIK-C H gene using NdeI and SpeI, generating CAM-AIK H II cDNA."
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"The chimeric CAM-AIK H I and II cDNA were cloned into the pME18S vector, generating pME-CAM-AIK H I and pME-CAM-AIK H II."
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"CAM-AIK H I, in which region II originated from the CAM-70 H protein, was unable to induce any syncytia at this time point ( Fig. 5 B)."
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"In CHO/SLAM cells, CAM-AIK H II induced syncytia to a similar extent as the AIK-C H protein at 24 h p."
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"In CHO/CD46 cells, CAM-AIK H II, in which region II was derived from the AIK-C H protein, induced syncytium formation, although the extent was less than that induced by the AIK-C H protein ( Fig. 5 B)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CAM-AIK H I did not produce any syncytia at this time point ( Fig. 5 C)."
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"Region I was also thought to play a role in the low CD46-dependent fusion-inducing ability of the CAM-70 H protein, given that the fusion-inducing ability of CAM-AIK H II in CHO/CD46 cells was observe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Given that the fusion-inducing ability of the CAM H N455T mutant was still lower than that of CAM-AIK H II, it was expected that either G505 or E603 in addition to N455 could result in the lower CD46-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, fusion-inducing ability of the CAM H N455T + E603G combination mutant was still lower than that of CAM-AIK H II ( Fig. 5 B)."
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"In CHO/SLAM cells, CAM H G505D induced syncytium formation equally as well as CAM-AIK H II and the AIK-C H protein at 24 h p."
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"t., although it was less extensive than that induced by CAM-AIK H II and the AIK-C H protein."
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