IndraLab

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OTUD6A inhibits gemcitabine. 3 / 3
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"Notably, treatment with the ATR inhibitor VE-821 and the Chk1 inhibitor GDC-0575 abrogated the decreased gemcitabine sensitivity induced by overexpression of OTUD6A in UMUC3 cells (Fig. 6j, k and Supplementary Fig. 10o-q)."
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"Notably, ectopic expression of CDC6 rescued the hypersensitivity to gemcitabine, methotrexate and HU caused by OTUD6A knockdown (Fig. 6l, m, Supplementary Fig. 10c, d and Supplementary Fig. 12a-e)."
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"Consistent with the observation from in vitro experiments, overexpression of CDC6 rescued the increased chemosensitivity caused by OTUD6A knockdown in gemcitabine-treated T24 tumours (Fig. 6u, v and Supplementary Fig. 12p, q)."
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