IndraLab

Statements

Cholesterol inhibits ACE2. 4 / 4
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"The depletion of cell membrane cholesterol reduced the risk of anSARS-CoV-2 infection by reducing the turnover of ACE2 and furin protease in the lipid rafts."
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"The loss of cholesterol directly impacts inflammation and induces ACE2 shedding by ADAM17 [184,186]."
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"Interestingly, in a diabetic mouse model characterized by elevated cholesterol with increased age and disease, ACE2 was predominantly found in cholesterol-rich GM1 membrane structures that facilitate endocytosis and cholesterol depletion caused ACE2 to move from GM1 lipid to PIP2 lipid domains, thereby decreasing virus uptake and infectivity (Wang et al, 2023)."
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"Glende [XREF_BIBR] believes that cholesterol consumption does not reduce the amount of ACE2 protein on the surface of Vero cells."
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