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USP8 activates Parkinson Disease. 2 / 2

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"However, two in vivo studies have shown that inhibition of USP8 either by knockdown or pharmacological inhibitors rescued PD phenotypes in PINK1 knockout (KO) or α-synuclein Drosophila models [89,90] [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination."

37981592

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP8 activates Parkinson Disease. 2 / 2

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