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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP19 activates SNCA. 3 / 3

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"Recently, the DUB, USP19, was shown to promote misfolded alpha-synuclein secretion [XREF_BIBR]."

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"However, under this condition, wild type (WT) USP19 is able to promote the secretion of misfolded alpha-Synuclein (alpha-Syn) in a dose dependent manner, as demonstrated previously 3."

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"Although USP19 stimulates alpha-synuclein secretion, exosome dependent tau secretion is not enhanced.113 4 Alternative Spreading Mechanisms."

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Statements

USP19 activates SNCA. 3 / 3

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