IndraLab
Statements
reach
"Briefly, the genetic models of PD are based on the genes associated with monogenic PD such as α-synuclein (α-syn), leucine rich repeat kinase 2 (LRRK2), parkin, PTEN-induced putative kinase 1 (PINK1), ubiquitin carboxyl terminal hydroxylase isozyme L1 (UCH-L1) and protein deglycase DJ-1, and most of these genetic models do not display clear degeneration of dopaminergic neurons in the SN or motor deficits (Duty and Jenner, 2011; Stoker and Greenland, 2018)."
reach
"In certain cases, the etiology of this disease is closely related to certain gene mutations which include synuclein, alpha (SNCA), Parkin RBR E3 ubiquitin protein ligase (PARK2), Parkinson's disease protein 7 precursor (PARK7), PTEN-induced putative kinase 1 (PINK1), ubiquitin carboxy-terminal hydrolase L1 (PARK5), and leucine-rich repeat kinase 2 (LRRK2) (41)."