IndraLab

Statements

USP9X activates Ubiquitin. 5 / 5
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"Myeloid cell leukemia-1 was expressed in abnormally high levels in CML, which is related to chemotherapy resistance and disease recurrence.143 WP1130, an inhibitor of the deubiquitin enzyme USP9X, enhanced the ubiquitin degradation of BCR-ABL, resulting in its accumulation in aggresomes, and down-regulated myeloid cell leukemia-1 to promote the apoptosis of imatinib-sensitive and drug-resistant CML cells."
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"Depletion of USP9x increased the incorporation of ubiquitin into AMOT (XREF_FIG)."
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"The absence of USP9X enhances the formation of ubiquitin clusters on the lysosomal surface, thus triggering autophagosome engulfment, and also promotes the formation of K63-linked polyubiquitin chains on the TAK1 complex, leading to its activation and subsequent activation of AMPK (Jia et al., 2022; Nguyen et al., 2023; Shariq et al., 2024)."
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"USP9X can also modulate ubiquitin ligase SMURF1, a negative regulator of TGFbeta and BMP signaling that controls tumor cell migration and invasion by targeting Rho family proteins [XREF_BIBR]-[XREF_BIBR]."
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"Both Usp9x KD and G9 treatment increased Ets-1 ubiquitin content (XREF_FIG)."
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