IndraLab

Statements

Malonaldehyde inhibits CTSB. 4 / 4
| 4
reach
"Both HNE and MDA inhibited the cysteine proteases cathepsin B and L at a concentration of 1 microM by 88%-94% and this effect was due to HNE and MDA adducts in the active center of these proteases [XREF_BIBR]."
26437435
reach
"These observations illustrate that excessive MDA in lysosomes reduces cathepsin B activity during HIRI."
35793548
reach
"HNE- and MDA-modified POS in concentrations of 1 mg/ml reduced activities of cysteine proteases cathepsin B and L by 88–95% and, furthermore, inhibited aspartic protease cathepsin D activity by 92–96%[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19895809
reach
"Lysosomal fractions were isolated from primary human RPE cell cultures, incubated with increasing concentrations of HNE or MDA, and analyzed for activities of cysteine proteases cathepsin B and L. Bot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19895809