IndraLab

Statements

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"To investigate the role of RAD23B in PSMD7-induced GC cell proliferation, migration, and invasion, we ectopically expressed RAD23B in AGS cells (P < 0.05, Figure 5A)."
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"PSMD7 knockdown repressed, whereas PSMD7 overexpression enhanced, the proliferation, migration, and invasion of GC cells."
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"Thus, RAD23B participated in PSMD7-enhanced malignant behaviors of GC cells."
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"Thus, PSMD7 promoted the malignant behavior and DDP resistance of GC cells by deubiquitinating and stabilizing RAD23B.In summary, we firstly investigated the overexpression of PSMD7 in GC and verified that PSMD7 has the potential to predict poor prognosis."
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"Furthermore, PSMD7 silencing inhibited GC tumor growth in vivo."
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"Moreover, PSMD7 knockdown suppressed the in vivo growth of GC cells and enhanced the efficiency of DDP treatment for tumor-bearing mice."
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"PSMD7 promotes the proliferation, migration, and invasion of GC cells."
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"PSMD7 promoted cell viability, apoptosis resistance, and DNA damage repair in GC cells upon cisplatin (DDP) treatment."
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