IndraLab

Statements

USP14 deubiquitinates FASN. 5 / 5
| 5
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"USP14 further promotes FASN deubiquitination and inhibits FASN breakdown, boosting TG production and fatty liver (107)."
40292292
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"NAFLD is a major type of metabolic disorder disease that has a high risk of progression to HCC, and USP14 deubiquitinates FASN by directly interacting with it and promoting FASN stability [87]."
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"Since USP14 reduced FASN protein levels in cancer cells, it was necessary to confirm the deubiquitination of FASN by USP14."
| PMC
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"As shown in Figure 4b,c, USP14 slightly reduced FASN ubiquitination."
| PMC
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"Ubiquitination assays indicated that the polyubiquitination of FASN was increased by USP14 silencing in NPC cells (Fig. 4j), demonstrating that USP14 stabilises the FASN protein by inhibiting its ubiquitin-proteasome degradation in NPC cells."
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