IndraLab

Statements

USP1 inhibits FUS. 5 / 5
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"Stalled forks are protected by a plethora of repair and replication factors, including RIF1, which inhibits end resection, the MRN-interacting protein MRNIP, the TLS suppressor USP1 which regulates PCNA via de-ubiquitination, HR proteins (RAD51, BRCA1, BRCA2, FANCD2), and RADX which regulates RAD51 [30,68–73]."
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"Recently, the deubiquitinating (DUB) enzyme USP1 was shown to directly remove the monoUb from PCNA, leading to the suggestion that USP1 is required to suppress the error-prone activity of TLS [XREF_BIBR]."
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"Thus, by reversing PCNA monoubiquitylation, USP1 helps to limit the unscheduled deployment of error-prone TLS polymerases to preserve genome integrity 8 ."
35365626
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"USP1 de-ubiquitination activity suppresses TLS-mediated gap filling."
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"Accordingly, deficiency of USP1 leads to elevation of PCNA-Ub levels and disrupts TLS regulation [XREF_BIBR]."
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