IndraLab

Statements


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"Inactivation of USP14 Perturbs Ubiquitin Homeostasis and Delays the Cell Cycle in Mouse Embryonic Fibroblasts and in Fruit Fly Drosophila."

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"49, 50 Knocking-down of USP14 arrested cell cycle at G2/M phase."

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"To explore the underlying mechanism by which USP14 promotes cell proliferation in LNcap cells, we monitored the cell cycle progression of each group exposed to various concentrations of IU1 (25, 50, 100muM) and found that inhibition of USP14 activity dramatically induced G0/G1 cell cycle arrest at different time points (0, 6, 12, 24, 48h) (XREF_FIG)."

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"USP14 knockdown or treatment with USP14 inhibitor IU1 induced G0/G1 cell cycle arrest and suppressed cell proliferation in AR-positive and ER-negative breast cancer cells and androgen responsive prost[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Downregulation of USP14 expression arrested the cell cycle, which may be related to beta-catenin degradation."