IndraLab

Statements

OTUD7B activates LEF1. 5 / 5
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"Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to an increased interaction with beta-catenin in the nucleus while not noticeably affecting ubiquitination on LEF1."
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"Compared to FOPflash luciferase levels, both USP36 and OTUD7B increased the luciferase activities (TOPflash), but OTUD7B significantly enhanced LEF1 activity to a greater extent (6.64-fold) than USP36 did (2.04-fold) (Figure 1C)."
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"Figure 1D demonstrates that the loss of OTUD7B significantly suppressed LEF1 activity."
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"As a result, we hypothesized that OTUD7B promotes Wnt signaling by facilitating the nuclear localization of LEF1 and/or its interaction with β-catenin within the nucleus."
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"The reason for caution lies in the catalytic-independent function of OTUD7B in activating LEF1."
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