IndraLab

Statements

reach
"Additionally, reduced levels of BAP1 induce aerobic glycolysis, which favors tumor growth (64)."
35098108
reach
"XREF_FIG shows that BAP1 +/- fibroblasts transduced with AdBAP1 had reduced glycolysis and glycolytic capacity; in contrast, AdC91S was ineffective at reducing glycolysis (rate of glycolysis in BAP1 +/- transduced with : AdGFP 24.94 +/-1.77 mpH and min, AdBAP1 6.92 +/-0.24 mpH and min, AdBAP1 (C91S) 20.33 +/-2.92 mpH and min; glycolytic capacity : AdGFP 30.33 +/-1.71 mpH and min, AdBAP1 11.50 +/-0.43 mpH and min, AdC91S 25.08 +/-3.25 mpH and min)."
28665402
reach
"The oxygen-dependent mechanisms that cause HIF-1α degradation and the genes that suppress HIF-1α in hypoxia have been studied in detail (10, 34), while the gene products that by facilitating HIF-1α expression and activity in hypoxia influence tumor invasion and metastases, remain largely unknown.We reported that reduced BAP1 levels increase aerobic glycolysis (5)."
36656861
reach
"In melanoma, BAP1 deficiency significantly elevated anaerobic glycolysis levels, leading to more lactate production in tumor cells [11]."
39587076