IndraLab

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TFPI increases the amount of USP22. 7 / 7
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"These observations suggest the possibility that EPI induces USP22 protein expression posttranslationally in human breast cancers."
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"Further IHC analysis confirmed that EPI treatment markedly increased the protein expression of USP22, FOXO1, and ATGL in xenograft MDA-MB-231 breast cancer tissues, while USP22 inhibition largely suppressed EPI-induced up-regulation of both FOXO1 and ATGL (Fig. 4, F to I)."
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"EPI stimulation, which induced USP22 protein expression and promoted USP22-FOXO1 interaction, markedly inhibited FOXO1 polyubiquitination in USP22 WT cancer cells, and targeted USP22 deletion resulted in a significant increase in FOXO1 ubiquitination and reduced FOXO1 protein expression even with EPI stimulation (Fig. 4P)."
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"Because EPI induces USP22 protein expression without affecting its mRNA levels, we tested if EPI-mediated signaling controls USP22 protein expression at posttranslational levels."
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"These findings suggest a potential mechanism whereby EPI may contribute to tumorigenesis, at least in part, through the up-regulation of USP22.We sought to investigate if EPI stimulates USP22 expression in breast cancer cells."
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"Similarly, EPI-induced USP22, FOXO1, and ATGL protein expression was also observed in 4T1 syngeneic breast cancer tissues by IHC staining."
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"Intriguingly, the induction of USP22 protein expression by EPI reached a plateau as early as 2 hours after treatment (Fig. 1G)."
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