IndraLab

Statements

TIMP1 binds ITGB1. 9 / 9
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"These findings imply that the interaction between TIMP1 and ITGB1/CD63 may contribute to maintaining the integrity of the blood-brain barrier, which is vital for neuroprotection [82]."
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"This finding implies a potential involvement of the Timp1-Itgb1 / Cd63 interaction in microglia migration."
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"Our data suggest that STAT3 can be activated by a cooperative interaction of TIMP-1, CD63 and ITGB1."
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"Further examination of these receptor-ligand pairs showed that both Astro-2 and Vas-1 upregulated Timp1-Itgb1 / Cd63 after 24 h, which is linked to wound healing and amoeboid cell migration."
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"In human melanoma cell lines, TIMP interacts with ITGB1 and CD63 and assists melanomagenesis and resistance to the cell death program."
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"In HSPCs specifically, the tetraspanin CD63 in a complex with TIMP1 and the β1 integrin were shown to modulate adhesion and migration of human CD34+ HSPCs ( xref )."
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"In addition TIMP-1 binds to CD 63 and β1 integrin to promote epithelial cell proliferation and inhibit apoptosis [38,39] ."
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"Thus, we tested the contribution of TIMP1-β1 integrin interaction to fibroblast activation."
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"Moreover, through further analysis, we discovered significant upregulation of ligands and receptors such as Timp1-Cd63 , Timp1-Itgb1 , Timp1-Lrp1 , as well as Ccl2-Ackr1 and Cxcl2-Ackr1 within this region."
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