IndraLab

Statements

Progesterone activates KCNK2. 5 / 5
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"No statistical difference in oxytocin contraction was observed in tissues treated with progesterone plus arachidonic acid compared with the uterine strips treated with arachidonic acid alone or progesterone alone, suggesting that both arachidonic acid and progesterone activate TREK-1 mediated uterine relaxation to a similar extent Uterine stretch causes no further effect on progesterone induced uterine relaxation."
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"Importantly, in uterine strips treated simultaneously with progesterone and L-methionine, no significant reduction in uterine contraction was observed, and the uterine contraction was at levels similar to those in control tissues without progesterone or L-methionine treatment, suggesting opposing effects of L-methionine and progesterone on TREK-1 channel mediated uterine relaxation TREK-1 activator arachidonic acid causes no further effect on progesterone induced uterine relaxation."
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"To determine whether the progesterone induced changes in uterine contraction are related TREK-1 activity, we tested the effects of TREK-1 inhibitor L-methionine (1 mM)."
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"The protein amount of TREK-1 was significantly enhanced in uterine strips treated with progesterone compared with control non treated uterine strips."
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"The low levels of TREK-1 in proliferative phase endometrium, led us to examine whether progesterone might be driving TREK-1 down-regulation given its critical role in secretory endometrium."
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