IndraLab
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"These results confirmed earlier obtained data, suggested that GK-2 stimulates phosphorylation of TrkA receptor and synthesis of heat shock proteins Hsp32 and Hsp70, activates selectively PI3K and Akt signaling cascade that is important for cell survival, but does not activate MAPK and Erk pathway, associated not only with cell survival but also with cell differentiation [28]."
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"Conversely, in BI-ALCLs and cALCLs there was an enrichment in genes involved in the neurotrophin signaling pathway (NTRK1, NTRK2, NTF3, NGF), which in turn activates the JAK/STAT, PI3K/Akt and MEK/ERK signaling cascades to promote cell proliferation, differentiation and survival [52,53]."
| PMC
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"Taken together, Ntrk1 might promote the viability, proliferation and inflammatory response of mesangial cells by stimulating the activation of p38 and ERK signaling pathways.In previous studies, the AKT signaling pathway has been found to be activated in mesangial cells, which represents a key mechanism for promoting the proliferation and inflammatory response of mesangial cells in rats with MsPGN [2, 21, 32]."
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"Furthermore, the data show that even for the population of patches that form associated with mitochondria there are two distinct subpopulations with dedicated roles in the formation of filopodia and fission, respectively.The concentration profile of NGF induced fission on axonal mitochondria is consistent with activation of the TrkA receptor (Kaplan et al., 1991) that activates both PI3K and Erk signaling."
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"Similarly, the administration of ABG001 (tetradecyl 2,3-dihydroxybenzoate), a neuritogenic substance, enhanced the survival and neurite growth of newborn cells in adult hippocampal via TrkA receptor triggered ERK and PI3K-Akt-mTOR signaling pathways, that leads to an enhanced preferential spatial cognitive function."
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"Activating transcription factor 3 (ATF3) and MAPK pathway related proteins (ERK1/2), tropomyosin receptor kinase A (TrkA), calcitonin gene related peptide (CGRP) and transient receptor potential vanilloid 1 (TRPV1) were upregulated 7th and 14th days after 2 mg/kg and 10 mg/kg of PTX administration."
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"Spicatoside A, a steroidal saponin discovered to be present in the Liriope platyphylla extract, induces neurite outgrowth in PC12 cells and NGF synthesis in astrocytes via the TrkA receptor-mediated activation of PI3-kinase and ERK1/2, which controls long-term potentiation and neuronal activity [ xref ]."
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"At molecular level, our findings indicate that ectopic expression of a mutated form of Spry4 (Y53A), in which a conserved tyrosine residue was replaced, fail to block both TrkA mediated Erk and MAPK activation and neurite outgrowth induced by NGF, suggesting that an intact tyrosine 53 site is required for the inhibitory effect of Spry4 on NGF signaling."
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"In PC12 cells and primary dorsal root ganglion neurons, RGS12 sustains nerve growth factor (NGF)-driven ERK activity and, therefore, neurite outgrowth by scaffolding a complete MAPK cascade, including the NGF-receptor TrkA, activated H-Ras, B-Raf, MEK2, and ERK proteins XREF_BIBR."
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"Since target innervation of BFCNs is TrkA dependent and the timing of maximal ERK activation in these neurons correlates with the establishment of target innervation, TrkA mediated activation of the ERK pathway may play a crucial role in the maintenance of target innervation by BFCNs."
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"For example, in PC12 cells, activated EGFR rapidly undergoes the clathrin based endocytosis and the following degradation, whereas activation of TrkA, a receptor for NGF, induces its translocation to long lived signalling endosomes, where TrkA avoids degradation and mediates sustained ERK activation 59."
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"The nociceptive activity of NGF is mediated through the activation of TrkA and p75NTR receptors on sensory nerve endings and of the corresponding downstream signaling cascades, particularly TrkA-activated Erk and PLC–1γ pathways and p75NTR-mediated c-jun activation [12], [26], [27]."
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"In addition to models, numerous experimental studies have collected population and single-cell data under various conditions, including BRAF inhibitor treatment in single melanoma cells [209], MEK and ERK kinase activities in PC12 cells [176], MAP kinase activities induced by EGF/NGF [78], single-cell ERK dynamics under various inhibitors and perturbations [210], NGF/TrkA-initiated ERK1/2 signaling kinase activities [211], single-cell ERK and AKT activity time course data for controlling the cell cycle [208], single-cell MAPK kinetics under computer-controlled temporal stimulations [212], crosstalk between the JNK and p38 signaling pathways [213], correlated ERK and AKT activities induced by G-protein-coupled receptors [214], ERK and AKT signaling in response to various growth factors [204], kinase activities in the three MAPK modules, the NF-κB and p38 pathways [80], and the dynamics of EGFR–Ras–ERK signaling that enhance heterogeneity in target gene expression [215]."
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"The kinetics of RTK and ERK signaling is critical to its function, in that the apparently divergent effects of RTK and ERK signaling on proliferation versus differentiation are explained by the ability of Ngf and Ntrk1 to activate ERK in a sustained manner, whereas Fgf induces strong, transient ERK activation."
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"In our previous study, we revealed that the L. platyphylla extract contains spicatoside A ( xref ), a steroidal saponin that exerts a neurotrophic effect by inducing neurite outgrowth in PC12 cells and by inducing NGF synthesis in astrocytes through TrkA receptor-mediated PI3-kinase and ERK1/2 activation of CREB, which regulates neuronal function and LTP [ xref ]."