"It also strongly stimulated KRAS−BRAF and KRAS−CRAF interactions and inhibited RAF intramolecular interaction with potencies similar to GDC-0879 (Fig. xref , f; Supplementary Fig. xref )."
"Consistent with this, the interaction of KRAS G12V with BRAF and CRAF gatekeeper mutants was resistant to GDC-0879 (type I), but not to AZ-628 (type II) in BRET dose-response experiments (Fig. xref and Supplementary Fig. xref )."