IndraLab

Statements

BRAF binds KRAS and RAF1. 3 / 3
| 3
sparser
"Specifically, binding of C-RAF and B-RAF to KRAS-GTP or KRAS G12D dimers via their RBD (Ras binding domain) and CRD (cysteine-rich domain), facilitates RAF membrane localization, dimerization, release of auto-inhibition and induction of multiple phosphorylation/de-phosphorylation events that lead to RAF activation [ xref , xref , xref ]."
| PMC
sparser
"It also strongly stimulated KRAS−BRAF and KRAS−CRAF interactions and inhibited RAF intramolecular interaction with potencies similar to GDC-0879 (Fig.  xref , f; Supplementary Fig.  xref )."
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sparser
"Consistent with this, the interaction of KRAS G12V with BRAF and CRAF gatekeeper mutants was resistant to GDC-0879 (type I), but not to AZ-628 (type II) in BRET dose-response experiments (Fig.  xref and Supplementary Fig.  xref )."
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