IndraLab

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USP21 deubiquitinates H2Aub. 3 / 3
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"The deubiquitination of H2Aub by USP16 is also a prerequisite for zygotic genome activation during the maternal-to-zygotic transition in mouse oocytes [41]."
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"By deubiquitinating H2Aub, USP16 facilitates the phosphorylation of histone H3 Ser10 and chromosome segregation at the onset of mitosis [14]."
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"As a potential antagonist of H2A ubiquitination by Polycomb Repressive Complex 1 (PRC1), USP16 deubiquitinates H2Aub at promoter regions."
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