IndraLab

Statements

Ubiquitin inhibits KCNH2. 5 / 5
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"Two E3 ubiquitin ligases, Hrd1 and Doa10 are known to mediate the proteasomal degradation of HMG-CoA reductase Hmg2 and squalene epoxidase Erg1 with accumulation of the toxic sterols in cells, but the deubiquitinases (DUBs) involved are unclear."
33524398
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"Ubiquitin dependent recruitment of membrane proteins to lipid rafts has been described previously 81 and could be involved in the ubiquitin dependent degradation of WT-hERG following extracellular K + -depletion 82."
30988392
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"Our results show that the ubiquitin ligase Nedd4-2 down-regulates I hERG1 measured in a mammalian cell line."
21463633
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"We have previously shown that mature hERG channels are degraded by ubiquitin ligase Nedd4-2 via enhanced channel ubiquitination."
23589291
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"Extracellular K + -depletion and high salt or acidity also triggered Ub dependent degradation of the wild-type HERG channel and LDL receptor, respectively, presumably by conformational destabilization [XREF_BIBR, XREF_BIBR]."
21571517