IndraLab

Statements

CYLD inhibits STAT1. 9 / 9
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"CYLD Impairs Activation of STAT1."
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"Taken together, we demonstrated that SPATA2 and CYLD attenuate STAT1 accumulation and activation in CRC cells, resulting in inhibited expression of the T-cell chemokines CXCL9, CXCL10, and CXCL11 ( Figure 4C )."
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"Thus, the inhibition of both STAT1 and NF-κB by CYLD is critical for the control of S. aureus in macrophages."
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"CYLD inhibits STAT1 signalling in MDMs."
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"CYLD inhibits STAT1, MyD88, and NOD2 signaling in S. aureus-infected M1-polarized macrophages."
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"Here we showed a redundant role of SPATA2 and CYLD in the regulation of STAT1 activation and IFN-γ-induced genes ( Figure 2 ) in tumor cells.Previous reports suggested that CYLD impairs STAT1 activation in bone marrow-derived macrophages (37) or in thymic epithelial cells (38) but the mechanism underlying this regulation is still unclear."
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"To study how CYLD reduces STAT1 activation and nuclear accumulation in IFN-gamma-stimulated Lm infected BMDM, we analyzed whether CYLD might directly bind to STAT1."
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"Our data show that CYLD is strongly expressed in the dermal macrophages and monocyte-derived macrophages (MDMs) of AD patients and that CYLD impairs STAT1- and NF-κB-dependent control of S. aureus in macrophages."
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"Mechanistically, we found that SPATA2 and CYLD prevent STAT1 accumulation and activation in vitro."
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