IndraLab

Statements

USP1 increases the amount of USP1. 4 / 4
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"Comparing the mRNA expression of USP1 and USP43 in EWS cell lines from DepMap portal (32), USP1 is overexpressed in EWS cell lines compared with USP43 (Fig. 1C)."
37478161
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"The USP1 shRNA efficiently inhibited the expression of USP1 which was monitored at the transcript level (Figures S4A and S4B) as well at the protein level (Figure S4C)."
37250303
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"The important regulatory role of USP1 in DNA repair, supported by the finding that USP1 gene knockout in model systems leads to DNA damage hypersensitivity [XREF_BIBR - XREF_BIBR], together with the observation that USP1 is frequently overexpressed in tumors, suggests that USP1 could be a relevant target for cancer therapy, whose inhibition might contribute to overcome chemoresistance."
23937906
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"The mRNA level of USP1 was decreased by siRNA of USP1, and migration was not affected (data not shown)."
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