IndraLab

"These results further confirmed a close interaction between BAP1 and IP3R. Overexpression of BAP1 significantly increased the expression of IP3R, while the knock down of BAP1 reduced the expression ( xref C and 7D)."

"Taken together, these results indicated that DIM could induce ferroptosis to exert anti-cancer effects via BAP1-IP3R axis, suggesting its effective therapeutic potential in gastric cancer."

"Ye et al .'s study [ xref ] showed that 3,3'-diindolyl methane can induce ferroptosis in BCC-823 GC cells and can induce ferroptosis through BAP1-IP3R axis to play an anticancer role, suggesting its effective therapeutic potential in GC."

"Mechanistically, BAP1 interacted with IP3R and increased cardiomyocytes’ Ca 2+ level, causing mPTP opening and mitochondrial dysfunction, promoting H/R-induced cardiomyocytes’ ferroptosis."

"In gastric cancer, DIM exerts antitumor effects through multiple mechanisms: Induction of ferroptosis via the BAP1-IP3R axis [ xref ]; STIM1-mediated store-operated calcium entry leading to cell death [ xref ]; inhibition of proliferation and induction of apoptosis via the TRAF2-p38 signaling pathway [ xref ]; potentiation of paclitaxel’s antitumor effects through the Akt/FOXM1 signaling cascade [ xref ]; suppression of cell growth via Hippo signaling pathway activation [ xref ]; activation of the aryl hydrocarbon receptor pathway, promoting its nuclear translocation, inducing apoptosis, delaying cell cycle progression, and inhibiting proliferation [ xref ]."

"Studies have shown that DIM plays an anticancer role by inducing ferroptosis in gastric cancer cells through the BAP1–IP3R axis [ xref ]."

"3,3'-Diindolylmethane induces ferroptosis by BAP1-IP3R axis in BGC-823 gastric cancer cells."