IndraLab

Statements

sparser
"β 1 integrins and hERG1 channels form a functional plasma membrane complex."
24270902
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"KV11.1 interacts with β1 integrins in PDAC, which is a tumor-specific feature of KV11.1 channels (Arcangeli and Becchetti, 2017)."
33841132
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"On the whole, these data indicate that the hERG1 protein associates with beta(1) integrins and modulates adhesion receptor signaling."
15800067
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"We conclude that the interaction of β 1 integrins with hERG1 channels in cancer cells stimulated distinct signaling pathways that depended on the conformational state of hERG1 and affected different aspects of tumor progression."
28377405
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"In the mesoderm phase of rESCs, the interaction of ERG1 with Integrin β1 can activate the AKT pathway by recruiting and phosphorylating PI3K p85 and focal adhesion kinase (FAK) to further phosphorylate AKT."
33426760
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"This interaction was not detected in cardiomyocytes because of the presence of the hERG1 auxiliary subunit KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1), which blocked the β 1 integrin-hERG1 interaction."
28377405
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"HERG1 is often dysregulated in cancer and physically interacts with integrin to modulate adhesion dependent intracellular signalling cascades, including cell adhesion, invasion, and proliferation [ xref , xref ]."
23033966
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"Indeed, σ1R is a key actor of the formation of [integrin:hERG] signaling hub at the plasma membrane, triggering AKT-dependent pro-metastatic cell behavior in vivo by stimulating migration , vascular endothelial vascular factor (VEGF) secretion, finally leading to migration, extravasation and angiogenesis in chronic myeloid leukemia and CRC ( xref ; xref ) ( xref )."
31780884
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"Expression of Sigmar1 regulates cell survival through controlling calcium homeostasis xref and modulates invasiveness and angiogenesis in glioblastoma cell lines via human voltage-dependent K+ channel human ether-a-go-go–related gene (hERG) and subsequent formation of hERG/β-integrin signaling complex and consequently activation of the PI3K/AKT pathway, and VEGF expression in myeloid leukemia and colorectal cancer cells xref , xref , xref ."
32305020
sparser
"Physical and functional interaction between integrins and hERG potassium channels."
15494025