IndraLab

Statements

KCNH2 binds Integrins. 36 / 36
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"β 1 integrins and hERG1 channels form a functional plasma membrane complex."
24270902
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"51 There is evidence of an interaction between Kv11.1 channels and β 1 -integrins that in turn affects the migration."
31839145
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"Physical and functional interaction between integrins and hERG potassium channels."
15494025
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"By combining experimental data and quantitative modeling, we defined a novel signaling pathway by which β1 integrins and hERG1 interact to regulate f-actin organization and promote cell migration."
37923359
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"We conclude that the interaction of β 1 integrins with hERG1 channels in cancer cells stimulated distinct signaling pathways that depended on the conformational state of hERG1 and affected different aspects of tumor progression."
28377405
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"These results suggest that integrin-dependent signaling is mainly impaired by the disruption of the hERG1/β1 integrin complex irrespectively of hERG1 current block."
37923359
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"Our kinetic model sheds light into the dynamics of hERG1 and hERG1/β1 integrin complex trafficking."
37923359
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"We included a catalytically augmented internalization signal to reproduce the internalization peak that runs quasi-simultaneously to the peak displayed by the hERG1–integrin complex."
37923359
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"In particular, we posited the existence of a catalytic module that governs the internalization of free hERG1 molecules (CG species E ) but, that is, inhibited by the signal provided by the species A*, that is, activated by the hERG1–integrin complex."
37923359
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"In particular, our fits find that the activation rate k a that transduces the signal coming from the hERG1–integrin complexes is about 10 times larger in cancer cells than in HEK–hERG1."
37923359
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"In particular, hERG1 physically associates with β1 integrin (encoded by the ITGB1 gene), and the complex enhances the metastatic potential of BCa in vivo [16]."
39865220
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"Our findings delineate a novel mechanism, based on the hERG1–β1 integrin interaction, whose dynamics shows biphasic behavior: (1) integrin engagement stimulates hERG1 channel translocation to the plasma membrane, which increases I hERG1 amplitude and causes V rest hyperpolarization; (2) hERG1 assembles with the integrin and remains in the plasma membrane (i.e., is not degraded) in the closed conformation, which progressively restores the initial V rest ."
37923359
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"On the whole, these data indicate that the hERG1 protein associates with beta(1) integrins and modulates adhesion receptor signaling."
15800067
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"Indeed, σ1R is a key actor of the formation of [integrin:hERG] signaling hub at the plasma membrane, triggering AKT-dependent pro-metastatic cell behavior in vivo by stimulating migration , vascular endothelial vascular factor (VEGF) secretion, finally leading to migration, extravasation and angiogenesis in chronic myeloid leukemia and CRC ( xref ; xref ) ( xref )."
31780884
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"KCNH2 interacts with integrin β1 to modulate the activity of AKT."
38063256
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"Our previous findings have demonstrated that KCNH2 interacts with integrin β1 to regulate the differentiation of rat embryonic stem cells (rESCs) into cardiomyocytes ( xref )."
38063256
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"Our previous findings have demonstrated that KCNH2 interacts with integrin β1 to activate the AKT signaling pathway during the differentiation of rESCs into cardiomyocytes ( xref )."
38063256
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"Immunoprecipitation further confirmed that KCNH2 indeed interacted with integrin β1 ( xref )."
38063256
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"Taken together, these results suggest that KCNH2 can directly interact with integrin β1 to facilitate the phosphorylation of AKT to prevent apoptosis in the rat heart during embryonic development."
38063256
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"The present study confirmed that KCNH2 interacts with integrin β1 to regulate the phosphorylation level of FAK, which is one of the fundamental molecules in integrin-dependent pathways ( xref )."
38063256
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"The specificity of scDb assessed through a Peptide ELISA [ xref ] allow us to discriminate between hERG1 channel and hERG1/β1 integrin complex."
36142530
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"The evidences indicating that hERG1 binds β1 integrin through its transmembrane domains [17] are a further indication that the macromolecular complex formation is sensitive to channel gating ( Box 2 )[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30635161
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"We combine experimental data and mathematical modeling to offer a coherent explanation of the dynamics of hERG1 interaction with integrins, which governs f-actin organization and migration in cancer cells."
37923359
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"Molecules which target the CXCR4/β1 integrin/hERG1 complex may be attractive options for treatment of chemoresistant and/or relapsed B-ALL."
39102101
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"Finally, we studied how the interaction of β1 integrins with hERG1 affected cell signaling in our cell models."
37923359
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"Nonetheless, a rigorous definition of the role of hERG1 current in ECM-activated signals will require direct structural studies about the scDb–hERG1–β1 interaction with the complex and hERG1 interaction with β1 integrin in different conformational states."
37923359
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"Expression of Sigmar1 regulates cell survival through controlling calcium homeostasis xref and modulates invasiveness and angiogenesis in glioblastoma cell lines via human voltage-dependent K+ channel human ether-a-go-go–related gene (hERG) and subsequent formation of hERG/β-integrin signaling complex and consequently activation of the PI3K/AKT pathway, and VEGF expression in myeloid leukemia and colorectal cancer cells xref , xref , xref ."
32305020
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"In the mesoderm phase of rESCs, the interaction of ERG1 with Integrin β1 can activate the AKT pathway by recruiting and phosphorylating PI3K p85 and focal adhesion kinase (FAK) to further phosphorylate AKT."
33426760
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"HERG1 is often dysregulated in cancer and physically interacts with integrin to modulate adhesion dependent intracellular signalling cascades, including cell adhesion, invasion, and proliferation [ xref , xref ]."
23033966
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"The interaction of Kv11.1 (HERG) with β-integrin is a prominent example of this situation xref that offers an opportunity to target tumor cells without altering cardiac function, which is the risk associated with HERG inhibition."
36632474
reach
"We included a catalytically augmented internalization signal to reproduce the internalization peak that runs quasi-simultaneously to the peak displayed by the hERG1–integrin complex."
37923359
reach
"In particular, we posited the existence of a catalytic module that governs the internalization of free hERG1 molecules (CG species E) but, that is, inhibited by the signal provided by the species A*, that is, activated by the hERG1–integrin complex."
37923359
reach
"In particular, our fits find that the activation rate k that transduces the signal coming from the hERG1–integrin complexes is about 10 times larger in cancer cells than in HEK–hERG1."
37923359
sparser
"Therefore, hERG1–R531C forms normal complexes with β1 integrins, whereas hERG1–K525C does not."
37923359
sparser
"This interaction was not detected in cardiomyocytes because of the presence of the hERG1 auxiliary subunit KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1), which blocked the β 1 integrin-hERG1 interaction."
28377405
sparser
"The dynamics of hERG1 interaction with integrins in cancer cells."
37923359