IndraLab

Statements

VEGFA activates NRP1. 25 / 37
| 21 4
reach
"Concomitantly, VEGFA-dependent activation of Neuropilin-1 (NRP-1) in the tip cells inhibits SMAD2/3 and SMAD1/5/8 signaling ultimately repressing the stalk cell phenotype and maintaining tip cell identity [21]."
33844116
reach
"To define the molecular mechanisms that regulate the cell autonomous function of Flt1 and Nrp1 in epidermal cells to initiate psoriasis formation, we first defined the transcriptional signature of epidermal cells induced by Vegfa in the presence or absence of Flt1 and Nrp1."
31934626
reach
"An important feature of Phactr-1 in human primary endothelial cells is that its regulation is mediated by VEGF-A 165 through two major interacting receptors, VEGF-R1 and NRP-1."
21939755
sparser
"In the absence of VEGFR-2, NRP-1 can still be activated by VEGF-A. Expression of NRP-1 in melanoma cells correlates with tumour cell invasive behaviour and formation of tube-like structures resembling vascular networks (vasculogenic mimicry)."
28977999
reach
"Both studies demonstrate that VEGF-A promotes axon guidance independently of its vascular roles through two receptors, either VEGFR2 (Ruiz de Almodovar et al., 2011) or neuropilin-1 (NRP1) (Erskine et al., 2011)."
24859987
reach
"VEGF-A addition also increased the number of microspikes in NRP1 depleted ECs on FN (XREF_FIG L, compare light gray columns)."
26051942
reach
"In the absence of VEGFR-2, NRP-1 can still be activated by VEGF-A."
28977999
reach
"Moreover, it is not yet clear how the VEGF- and ECM driven NRP1 pathways described above intersect with NRP1 mediated TGFbeta signalling, discussed in the next section."
26923176
reach
"VEGF-A 165 promotes the formation of a complex of NRP1 and KDR in endothelial cells, which is thought to be important for optimal VEGF signaling and function."
21653826
reach
"VEGF-A induces intracellular signaling by binding to one of two receptors: VEGF receptor-1 (VEGFR-1, previously termed fms-like tyrosine kinase-1 [Flt-1]) and VEGFR-2 (previously termed murine fetal l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27836681
reach
"On the contrary, excessive levels of VEGFA lead to junction zippering and loss of fat absorption, as observed upon blood endothelial cell-specific loss of the VEGFA sinks VEGFR1 and NRP1 (Fig. 2 B; Zhang et al., 2018)."
38051275
reach
"Unlike sema3C treated ECs, Nrp1 did not colocalize with CTbeta in cells treated with VEGF-A 165 (XREF_SUPPLEMENTARY and XREF_FIG)."
18723443
sparser
"This binding strongly inhibits the activation of NRP-1 by VEGF-A 165 , and the LPPR sequence is responsible for 75% of this inhibition [ xref ]."
32183142
sparser
"Concomitantly, VEGF-A-dependent activation of Neuropilin-1 (NRP-1) in the tip cells inhibits SMAD2/3 and SMAD1/5/8 signaling ultimately repressing the stalk cell phenotype and maintaining tip cell identity [ xref ]."
33844116
reach
"As shown in Figure XREF_FIG, VEGF-A rapidly induced complex formation of NRP-1 and VEGFR2 in HUVECs."
27517319
reach
"VEGFA 165 induces association of Nrp1, VEGFR2, and synectin to form a protein complex and drive intracellular trafficking of Nrp1 and VEGFR2 through specific endosomal compartments."
26849476
sparser
"NRP-1 can be activated by VEGF-A also in the absence of VEGFRs, triggering specific signal transduction pathways (e.g. p130Cas phosphorylation)."
28977999
reach
"VEGFR-1, but not VEGFR-2, is expressed in motor neurons of the facial nerve, leading to the assumption that VEGF-A induces the formation of a complex of VEGFR-1 and Nrp-1 that then transmits the VEGF-A signal [XREF_BIBR]."
23475067
reach
"However, recent biochemical studies demonstrated that Sema3A and VEGF-A bind to distinct domains of NRP1 [XREF_BIBR, XREF_BIBR] and induce NRP1 endocytosis through different pathways, suggesting that these NRP1 ligands function separately, rather than competitively."
21978864
reach
"As a consequence, VEGF-A induced NRP1 and GIPC1 and GIPC1 and Syx complex formation without the expression of VEGFR1 or VEGFR2."
26209534
reach
"VEGFA and semaphorin 3 A (Sema 3 A) can also activate neuropilin-1 (NRP1), VEGFR1 and recruit TAMs [137]."
37012233
reach
"Since GIPC1 interacts with neuropilin-1 XREF_BIBR, cells were treated with VEGFA (10 ng/ml) to determine whether the loss of cell viability caused by GIPC1 suppression could be overcome by a relevant mitogen."
21209904
reach
"Our data show that blocking Nrp1 signal transduction in proarteriogenic Mo/MΦs suppresses Erk phosphorylation (which is normally induced by Vegfa-stimulation of Nrp1), thus abrogating the angiogenic and arteriogenic effects of Htatip2 suppression in these cells.Increased expression of HTATIP2 is associated with decreased expression of Ang-1 in tumor cells (26)."
37847559
reach
"The HIV tat protein also mimics VEGF-A and HIV infection also upregulates NRP-1."
40008234
reach
"In addition, recent studies of the VEGFR co-receptor neuropilin-1 (Nrp-1) have shown that the C terminus of VEGF-A 165, particularly Arg 164, mediates high affinity binding of Nrp-1, increasing VEGFR activity [XREF_BIBR]."
25274272