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USP14 increases the amount of CXCR4. 2 / 2
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"We believe that this inherent increase in USP14 in T cells may underlie increased CXCR4 expression observed in the elderly."

"The physical interaction of CXCR4 and USP14 is paralleled by USP14-catalyzed deubiquitination of the receptor|We also observed that ubiquitination of CXCR4 facilitated receptor degradation, whereas overexpression of USP14 or RNAi-induced knockdown of USP14 blocked CXCL12-mediated CXCR4 degradation"