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USP18 binds GSDMD. 10 / 10
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"Together, these data suggest that USP18 binds to GSDMD and impairs GSDMD-mediated pyroptosis in an enzymatic activity-independent manner."
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"GSDMD-USP18 association was increased by different inflammasome activators (Fig. xref G)."
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"We observed that, similarly to wild-type (WT) USP18, enzymatically inactive mutant USP18 C64A could interact with GSDMD (Fig. xref H)."
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"Together, these data suggest that USP18 binds to GSDMD and impairs GSDMD-mediated pyroptosis in an enzymatic activity-independent manner."
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"We observed that the interaction between GSDMD and USP18/MIB2 showed no difference in WT GSDMD and I104N GSDMD-transfected cells (Fig. S6D and E)."
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"USP18 interacts with GSDMD and impairs GSDMD-mediated pyroptosis."
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"USP18 interacts with GSDMD and impairs GSDMD-mediated pyroptosis."
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"Reciprocal pull-down experiments also showed that GSDMD could associate with USP18 (Fig. S1D)."
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"Then, we observed that USP18 specifically interacted with GSDMD but not CASP1/4 (Fig. xref E)."
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"Reciprocal pull-down experiments also showed that GSDMD could associate with USP18 (Fig. xref D)."
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