IndraLab

Statements

USP15 inhibits DDX58. 5 / 7
| 5
reach
"USP21 and USP15 remove K63 linked polyubiquitin chains from RIG-I and block the ability of RIG-I to induce IFN-beta XREF_BIBR XREF_BIBR."
27824081
reach
"The knockdown of USP15 increases RIG-I K63 linked polyubiquitination, enhancing the IFN production, whereas the overexpression of USP15 decreases the type I IFN by blocking the transcription of IFN-beta in HEK293T infected with SeV."
33138315
reach
"USP21 and USP15 remove K63-linked polyubiquitin chains from RIG-I and block the ability of RIG-I to induce IFN-β 24,25 ."
27824081
reach
"For example, the deubiquitinating enzyme USP15 negatively regulates virusinduced IFN-I production by targeting RIG-I (84)."
34707613
reach
"In particular, USP3, USP21, USP25 and USP15 have all been shown to directly inhibit RIG-I."
28295214