IndraLab

Statements

CDKN2A inhibits BAP1. 5 / 5
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"To that end, a systematic literature review was performed of articles dealing with a loss of BRCA1-associated protein 1 (BAP1), methylthioadenosine (MTAP), 5-hydroxymethylcitosine (5-hmC), glucose transporter 1 (GLUT1), insulin like-growth factor II messenger RNA-binding protein 3 (IMP3), enhanced zeste homologue 2 (EZH2) staining, cyclin-dependent kinase inhibitor 2A (CDKN2A) homozygous deletion (HD) testing, soluble mesothelin, and microRNA quantification in cytological samples for the diagnosis of MPM versus reactive atypical mesothelial cells."
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"It is worth emphasizing that morphology alone is insufficient for a diagnosis of MIS, while demonstration of BAP1 loss by IHC or CDKN2A/p16 homozygous deletion by FISH are required [13,24]."
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"Loss of BAP-1 protein on IHC and homozygous deletion of the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene (p16) on chromosome 9p21 by FISH on cell blocks/biopsy establishes the diagnosis of MM an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The 2 peritoneal mesothelioma cases demonstrated loss of BAP1 but not p16."
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"Contribution of BAP1 loss and p16 (CDKN2A) deletion analysis to the definitive diagnosis of mesothelioma in effusion cytology."
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