IndraLab

Statements

OTUB1 inhibits MTOR. 3 / 3
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"On the molecular level, Otub1 deletion enhanced mTOR signaling in embryonic and adult lung tissues."
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"Mechanistically, the loss of OTUB1 increases mTOR activity in lung cells, which increases cell proliferation, decreases saccular air space, and prevents inhalation (Ruiz-Serrano et al., 2021)."
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"Blocking the mTOR by using CTLA-4-Ig, anti-IL-2 or rapamycin prevented Otub-1 protein expression and maintained GRAIL expression, which inhibited T cell proliferation [XREF_BIBR]."
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